Journal article
Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms
- Abstract:
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Aging facilitates the expansion of hematopoietic stem cells (HSCs) carrying clonal hematopoiesis-related somatic mutations and the development of myeloid malignancies, such as myeloproliferative neoplasms (MPNs). While cooperating mutations can cause transformation, it is unclear whether distinct bone marrow (BM) HSC-niches can influence the growth and therapy response of HSCs carrying the same oncogenic driver. Here we found different BM niches for HSCs in MPN subtypes. JAK-STAT signaling di...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 17.9MB, Terms of use)
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- Publisher copy:
- 10.1038/s43018-023-00607-x
Authors
Funding
Bibliographic Details
- Publisher:
- Springer Nature
- Journal:
- Nature Cancer More from this journal
- Volume:
- 4
- Issue:
- 8
- Pages:
- 1193-1209
- Place of publication:
- England
- Publication date:
- 2023-08-07
- Acceptance date:
- 2023-06-27
- DOI:
- EISSN:
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2662-1347
- ISSN:
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2662-1347
- Pmid:
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37550517
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1506252
- Local pid:
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pubs:1506252
- Deposit date:
-
2023-10-27
Terms of use
- Copyright holder:
- Grockowiak et al
- Copyright date:
- 2023
- Rights statement:
- © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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