Tubular epithelial syndecan-1 maintains renal function in murine ischemia/reperfusion and human transplantation.

Journal article

Syndecan-1, a heparan sulfate proteoglycan, has an important role in wound healing by binding several growth factors and cytokines. As these processes are also crucial in damage and repair after renal transplantation, we examined syndecan-1 expression in human control kidney tissue, renal allograft protocol biopsies, renal allograft biopsies taken at indication, and non-transplant interstitial fibrosis. Syndecan-1 expression was increased in tubular epithelial cells in renal allograft biopsie...

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Authors: Celie, J; Katta, K; Adepu, S; Melenhorst, W; Reijmers, R

• Publication status: Published
• Journal: Kidney international
• Volume: 81
• Issue: 7
• Pages: 651-661
• Publication date: 2012-04-01
• DOI: 10.1038/ki.2011.425
• EISSN: 1523-1755
• ISSN: 0085-2538
• Language: English
• Keywords: Fibrosis; Reperfusion Injury; Epithelial Cells; Mice, Inbred C57BL; Syndecan-1; Female; Intercellular Signaling Peptides and Proteins; Transplantation, Homologous; Kidney Transplantation; Mice, Knockout; Middle Aged; Kidney; RNA, Small Interfering; Cell Line; Male; Aged, 80 and over; Young Adult; Gene Knockdown Techniques; Humans; Adolescent; Base Sequence; Adult; Animals; Aged; Mice; Kidney Tubules