Journal article
Very large treatment effects in randomised trials as an empirical marker to indicate whether subsequent trials are necessary: meta-epidemiological assessment
- Abstract:
-
Objective: Most healthcare interventions provide modest benefits, but occasionally trials report very large improvements over existing treatments or inactive controls. This often leads to speculation that further trials may be unnecessary. We examined whether a very large effect (VLE, relative risk (RR) of ≤0.2 or ≥5) in a randomised trial could be an empirical marker that subsequent trials are unnecessary. Design: Meta-epidemiological assessment of existing... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- BMJ Publishing Group Publisher's website
- Journal:
- BMJ Journal website
- Volume:
- 355
- Article number:
- i5432
- Publication date:
- 2016-01-01
- Acceptance date:
- 2016-09-29
- DOI:
- ISSN:
-
1756-1833
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:647839
- UUID:
-
uuid:3fa2c745-9769-4c18-9d14-d6e724ca87ed
- Local pid:
- pubs:647839
- Source identifiers:
-
647839
- Deposit date:
- 2016-10-04
Terms of use
- Copyright holder:
- Nagendran et al
- Copyright date:
- 2016
- Notes:
- This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/.
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