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In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination.

Abstract:

Adjuvants are substances that enhance immune responses and thus improve the efficacy of vaccination. Few adjuvants are available for use in humans, and the one that is most commonly used (alum) often induces suboptimal immunity for protection against many pathogens. There is thus an obvious need to develop new and improved adjuvants. We have therefore taken an approach to adjuvant discovery that uses in silico modeling and structure-based drug-design. As proof-of-principle we chose to target ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0803453105

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
105
Issue:
29
Pages:
10221-10226
Publication date:
2008-07-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
34309

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