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Live hot, die young: transmission distortion in recombination hotspots.

Abstract:

There is strong evidence that hotspots of meiotic recombination in humans are transient features of the genome. For example, hotspot locations are not shared between human and chimpanzee. Biased gene conversion in favor of alleles that locally disrupt hotspots is a possible explanation of the short lifespan of hotspots. We investigate the implications of such a bias on human hotspots and their evolution. Our results demonstrate that gene conversion bias is a sufficiently strong force to produ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.0030035

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Role:
Author
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
3
Issue:
3
Article number:
e35
Publication date:
2007-03-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
200367

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