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High affinity agonist binding to cloned 5-hydroxytryptamine2 receptors is not sensitive to GTP analogs.

Abstract:

Agonists for GTP-binding protein (G protein)-coupled receptors are thought to bind with high affinity to the complex of receptor and G protein. Nonhydrolyzable GTP analogs have been shown to disrupt this complex and reduce the binding affinity for many agonists. Antagonists are thought to bind to the receptor whether or not it is coupled to the G protein, and therefore binding remains unchanged in the presence of GTP analogs. The binding of the serotonin 5-hydroxytryptamine (5-HT)2 receptor a...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Molecular pharmacology
Volume:
43
Issue:
6
Pages:
915-920
Publication date:
1993-06-05
EISSN:
1521-0111
ISSN:
0026-895X
URN:
uuid:3f90ed3b-ff6a-4a7a-89b3-119fa2a62204
Source identifiers:
113897
Local pid:
pubs:113897

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