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Journal article

Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation.

Abstract:

In XX female mammals a single X chromosome is inactivated early in embryonic development, a process that is required to equalise X-linked gene dosage relative to XY males. X inactivation is regulated by a cis-acting master switch, the Xist locus, the product of which is a large non-coding RNA that coats the chromosome from which it is transcribed, triggering recruitment of chromatin modifying factors that establish and maintain gene silencing chromosome wide. Chromosome coating and Xist RNA-m...

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Publication status:
Published

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Publisher copy:
10.1242/dev.056812

Authors


Senner, CE More by this author
Nesterova, TB More by this author
Dewchand, H More by this author
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Journal:
Development (Cambridge, England)
Volume:
138
Issue:
8
Pages:
1541-1550
Publication date:
2011-04-05
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:3f7e12db-d0ac-494b-962a-7cf8f358fb85
Source identifiers:
124342
Local pid:
pubs:124342

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