Journal article
Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation.
- Abstract:
-
In XX female mammals a single X chromosome is inactivated early in embryonic development, a process that is required to equalise X-linked gene dosage relative to XY males. X inactivation is regulated by a cis-acting master switch, the Xist locus, the product of which is a large non-coding RNA that coats the chromosome from which it is transcribed, triggering recruitment of chromatin modifying factors that establish and maintain gene silencing chromosome wide. Chromosome coating and Xist RNA-m...
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- Publication status:
- Published
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- Publisher copy:
- 10.1242/dev.056812
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Bibliographic Details
- Journal:
- Development (Cambridge, England)
- Volume:
- 138
- Issue:
- 8
- Pages:
- 1541-1550
- Publication date:
- 2011-04-01
- DOI:
- EISSN:
-
1477-9129
- ISSN:
-
0950-1991
- Source identifiers:
-
124342
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:124342
- UUID:
-
uuid:3f7e12db-d0ac-494b-962a-7cf8f358fb85
- Local pid:
- pubs:124342
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2011
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