Journal article
UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization
- Abstract:
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Hypoxia-inducible factor 1 (HIF-1) has been recognized as an important mediator of the reprogramming of carbohydrate metabolic pathways from oxidative phosphorylation to accelerated glycolysis. Although this reprogramming has been associated with the antioxidant and radioresistant properties of cancer cells, gene networks triggering the HIF-1-mediated reprogramming and molecular mechanisms linking the reprogramming with radioresistance remain to be determined. Here, we show that Ubiquitin C-t...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.6MB)
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- Publisher copy:
- 10.1038/s41598-017-06605-1
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Scientific reports Journal website
- Volume:
- 7
- Issue:
- 1
- Pages:
- 6879
- Publication date:
- 2017-07-31
- Acceptance date:
- 2017-06-15
- DOI:
- ISSN:
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2045-2322
- Pmid:
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28761052
- Source identifiers:
-
713221
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:713221
- UUID:
-
uuid:3f684f40-d849-4e4d-ab93-0cf45ddfd73b
- Local pid:
- pubs:713221
- Deposit date:
- 2017-10-18
Terms of use
- Copyright holder:
- Nakashima et al
- Copyright date:
- 2017
- Notes:
-
© The Author(s) 2017. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International
License, which permits use, sharing, adaptation, distribution and reproduction in any medium or
format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party material in this
article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the
material. If material is not included in the article’s Creative Commons license and your intended use is not permitted
by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the
copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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