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UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

Abstract:

Hypoxia-inducible factor 1 (HIF-1) has been recognized as an important mediator of the reprogramming of carbohydrate metabolic pathways from oxidative phosphorylation to accelerated glycolysis. Although this reprogramming has been associated with the antioxidant and radioresistant properties of cancer cells, gene networks triggering the HIF-1-mediated reprogramming and molecular mechanisms linking the reprogramming with radioresistance remain to be determined. Here, we show that Ubiquitin C-t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher version

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Publisher copy:
10.1038/s41598-017-06605-1

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Publisher:
Springer Nature Publisher's website
Journal:
Scientific reports Journal website
Volume:
7
Issue:
1
Pages:
6879
Publication date:
2017-07-31
Acceptance date:
2017-06-15
DOI:
ISSN:
2045-2322
Pubs id:
pubs:713221
URN:
uri:3f684f40-d849-4e4d-ab93-0cf45ddfd73b
UUID:
uuid:3f684f40-d849-4e4d-ab93-0cf45ddfd73b
Local pid:
pubs:713221
Language:
English
Keywords:

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