Journal article icon

Journal article

UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

Abstract:

Hypoxia-inducible factor 1 (HIF-1) has been recognized as an important mediator of the reprogramming of carbohydrate metabolic pathways from oxidative phosphorylation to accelerated glycolysis. Although this reprogramming has been associated with the antioxidant and radioresistant properties of cancer cells, gene networks triggering the HIF-1-mediated reprogramming and molecular mechanisms linking the reprogramming with radioresistance remain to be determined. Here, we show that Ubiquitin C-t...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41598-017-06605-1

Authors


Expand authors...
Publisher:
Springer Nature Publisher's website
Journal:
Scientific reports Journal website
Volume:
7
Issue:
1
Pages:
6879
Publication date:
2017-07-31
Acceptance date:
2017-06-15
DOI:
ISSN:
2045-2322
Pmid:
28761052
Source identifiers:
713221
Language:
English
Keywords:
Pubs id:
pubs:713221
UUID:
uuid:3f684f40-d849-4e4d-ab93-0cf45ddfd73b
Local pid:
pubs:713221
Deposit date:
2017-10-18

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP