IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.

Journal article

Interleukin-10 (IL-10) has various immunomodulatory actions depending on the target cell type. Some of these effects have been shown to be owing to its ability to down-regulate surface expression of markers, for example HLA-DR on macrophages and CD25 (IL-2 receptor alpha chain) on B cells. In this report we show that preincubation of IL-10 for 24 hr up-regulates expression of the activation marker CD25, but not HLA-DR on cloned T cells of various phenotypes such as CD4+, CD8+, CD4- CD8- alpha...

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Authors: Cohen, S; Katsikis, P; Feldmann, M; Londei, M

• Publication status: Published
• Journal: Immunology
• Volume: 83
• Issue: 3
• Pages: 329-332
• Publication date: 1994-11-01
• EISSN: 1365-2567
• ISSN: 0019-2805
• Language: English
• Keywords: Cells, Cultured; Receptors, Antigen, T-Cell, alpha-beta; CD4-Positive T-Lymphocytes; Humans; Up-Regulation; Clone Cells; Interleukin-2; Interleukin-10; Adjuvants, Immunologic; CD8-Positive T-Lymphocytes; Cell Division; HLA-DR Antigens; Lymphocyte Activation; Receptors, Interleukin-2; T-Lymphocytes; Receptors, Antigen, T-Cell, gamma-delta