Investigation into the neural correlates of emotional augmentation of clinical pain.

Journal article

Although depressive mood is an important psychological determinate of chronic pain, the neural circuitry that mediates its influence on the pain experience is largely unknown. We used functional magnetic resonance imaging (FMRI) to investigate the neurophysiological interactions between depressive symptoms and disease-relevant pain in rheumatoid arthritis (RA) patients. RA is associated with chronic joint pain and swelling, but peripheral joint pathology often does not fully explain the amoun...

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Authors: Schweinhardt, P; Kalk, N; Wartolowska, K; Chessell, I; Wordsworth, P

• Publication status: Published
• Journal: NeuroImage
• Volume: 40
• Issue: 2
• Pages: 759-766
• Publication date: 2008-04-01
• DOI: 10.1016/j.neuroimage.2007.12.016
• EISSN: 1095-9572
• ISSN: 1053-8119
• Language: English
• Keywords: Magnetic Resonance Imaging; Female; Humans; Brain; Middle Aged; Pain; Arthritis, Rheumatoid; Depression; Male