Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease.

Journal article

Previous studies have implicated brain serotonin 5-HT(1A) receptors in several CNS functions, including cognition, mood and emotional states. In Alzheimer disease (AD), cognitive impairment and behavioral symptoms are the main clinical features. However, the biochemical basis of such changes is poorly understood. Results from recent in vivo studies suggest that 5-HT(1A) receptors may be related to aggressive traits in healthy subjects. The present study investigated the state of 5-HT(1A) rece...

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Authors: Lai, M; Tsang, S; Francis, P; Esiri, M; Keene, J

• Publication status: Published
• Journal: Brain research
• Volume: 974
• Issue: 1-2
• Pages: 82-87
• Publication date: 2003-06-01
• DOI: 10.1016/s0006-8993(03)02554-x
• EISSN: 1872-6240
• ISSN: 0006-8993
• Language: English
• Keywords: Serotonin Receptor Agonists; Kinetics; Receptors, Serotonin; Prospective Studies; Membranes; 8-Hydroxy-2-(di-n-propylamino)tetralin; Alzheimer Disease; Temporal Lobe; Aged, 80 and over; Neuropsychological Tests; Female; Male; Ligands; Radioligand Assay; Humans; Aged; Aggression; Receptors, Serotonin, 5-HT1