Journal article
Synthetic tools for studying the chemical biology of InsP8
- Abstract:
- To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Supplementary materials, 4.2MB)
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(Version of record, pdf, 2.0MB)
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- Publisher copy:
- 10.1039/c5cc05017k
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Authors
Funding
National Institutes of Health
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Bibliographic Details
- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Chemical Communications Journal website
- Volume:
- 51
- Issue:
- 63
- Pages:
- 12605-12608
- Publication date:
- 2015-07-03
- Acceptance date:
- 2015-07-03
- DOI:
- EISSN:
-
1364-548X
- ISSN:
-
1359-7345
- Source identifiers:
-
551830
Item Description
- Language:
- English
- Pubs id:
-
pubs:551830
- UUID:
-
uuid:3f38c02c-f6ee-4177-985b-aa636c5f0de7
- Local pid:
- pubs:551830
- Deposit date:
- 2015-11-12
Terms of use
- Copyright holder:
- Riley et al
- Copyright date:
- 2015
- Rights statement:
- This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
- Licence:
- CC Attribution (CC BY)
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