Journal article icon

Journal article

Synthetic tools for studying the chemical biology of InsP8.

Abstract:
To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1039/c5cc05017k

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
More from this funder
Funding agency for:
L Potter, BV
National Institutes of Health More from this funder
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Chemical communications (Cambridge, England) Journal website
Volume:
51
Issue:
63
Pages:
12605-12608
Publication date:
2015-01-01
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
URN:
uuid:3f38c02c-f6ee-4177-985b-aa636c5f0de7
Source identifiers:
551830
Local pid:
pubs:551830
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP