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Synthetic tools for studying the chemical biology of InsP8

Abstract:
To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/c5cc05017k

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Funding agency for:
Potter, BVL
National Institutes of Health More from this funder
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Chemical Communications Journal website
Volume:
51
Issue:
63
Pages:
12605-12608
Publication date:
2015-07-03
Acceptance date:
2015-07-03
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Source identifiers:
551830
Language:
English
Pubs id:
pubs:551830
UUID:
uuid:3f38c02c-f6ee-4177-985b-aa636c5f0de7
Local pid:
pubs:551830
Deposit date:
2015-11-12

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