- Abstract:
- To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.0MB)
-
- Publisher copy:
- 10.1039/c5cc05017k
-
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- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Chemical communications (Cambridge, England) Journal website
- Volume:
- 51
- Issue:
- 63
- Pages:
- 12605-12608
- Publication date:
- 2015-01-01
- DOI:
- EISSN:
-
1364-548X
- ISSN:
-
1359-7345
- URN:
-
uuid:3f38c02c-f6ee-4177-985b-aa636c5f0de7
- Source identifiers:
-
551830
- Local pid:
- pubs:551830
- Language:
- English
- Copyright holder:
- Riley et al.
- Copyright date:
- 2015
- Notes:
- This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Journal article
Synthetic tools for studying the chemical biology of InsP8.
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