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Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles

Abstract:

Although host genetics influences susceptibility to tuberculosis (TB), few genes determining disease outcome have been identified. We hypothesized that macrophages from individuals with different clinical manifestations of Mycobacterium tuberculosis (Mtb) infection would have distinct gene expression profiles and that polymorphisms in these genes may also be associated with susceptibility to TB. We measured gene expression levels of >38,500 genes from ex vivo Mtb-stimulated macrophages in ...

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Authors


Thuong, NTT More by this author
Dunstan, SJ More by this author
Thorsson, V More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Journal:
PLoS Pathogens
Volume:
4
Issue:
12
Publication date:
2008-12-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:3f317dbd-6263-46aa-97cc-5ee5b51f66aa
Source identifiers:
92797
Local pid:
pubs:92797
Language:
English

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