- Abstract:
-
Although host genetics influences susceptibility to tuberculosis (TB), few genes determining disease outcome have been identified. We hypothesized that macrophages from individuals with different clinical manifestations of Mycobacterium tuberculosis (Mtb) infection would have distinct gene expression profiles and that polymorphisms in these genes may also be associated with susceptibility to TB. We measured gene expression levels of >38,500 genes from ex vivo Mtb-stimulated macrophages in ...
Expand abstract - Publisher copy:
- 10.1371/journal.ppat.1000229
-
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- Journal:
- PLoS Pathogens
- Volume:
- 4
- Issue:
- 12
- Publication date:
- 2008-12-05
- DOI:
- EISSN:
-
1553-7374
- ISSN:
-
1553-7366
- URN:
-
uuid:3f317dbd-6263-46aa-97cc-5ee5b51f66aa
- Source identifiers:
-
92797
- Local pid:
- pubs:92797
- Language:
- English
- Copyright date:
- 2008
Journal article
Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles
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