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Kir6.2-containing ATP-sensitive potassium channels protect cortical neurons from ischemic/anoxic injury in vitro and in vivo.

Abstract:

ATP-sensitive potassium (K(ATP)) channels are weak inward rectifiers that appear to play an important role in protecting neurons against ischemic damage. Cerebral stroke is a major health issue, and vulnerability to stroke damage is regional within the brain. Thus, we set out to determine whether K(ATP) channels protect cortical neurons against ischemic insults. Experiments were performed using Kir6.2(-/-) K(ATP) channel knockout and Kir6.2(+/+) wildtype mice. We compared results obtained in ...

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Publication status:
Published

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Authors


Barber, PA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
French, RJ More by this author
Journal:
Neuroscience
Volume:
144
Issue:
4
Pages:
1509-1515
Publication date:
2007-02-05
DOI:
EISSN:
1873-7544
ISSN:
0306-4522
URN:
uuid:3f2952d2-8697-4589-bb0d-47e773e39c08
Source identifiers:
79159
Local pid:
pubs:79159

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