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Journal article

Late sodium current associated cardiac electrophysiological and mechanical dysfunction

Abstract:

Late sodium current (INaL) is a small sustained inward current observed during the cardiac action potential plateau phase following decay of the early peak INa. The endogenous INaL is relatively small in normal hearts but exerts functionally significant effects on cardiomyocyte repolarization with potentially pro-arrhythmic effects in hearts with reduced repolarization reserve. Enhanced INa,L occurs in long QT syndrome 3 (LQTS 3) patients, and under a number of pathological and pharmacologica...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00424-017-2079-7

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
ORCID:
0000-0002-0928-341X
Publisher:
Springer Verlag Publisher's website
Journal:
Pflügers Archiv European Journal of Physiology Journal website
Volume:
470
Issue:
3
Pages:
461–469
Publication date:
2017-11-10
Acceptance date:
2017-10-09
DOI:
ISSN:
1432-2013 and 0031-6768
Pmid:
29127493
Source identifiers:
746124
Language:
English
Keywords:
Pubs id:
pubs:746124
UUID:
uuid:3f2522d1-0028-4cf5-9f2b-195dd26123ca
Local pid:
pubs:746124
Deposit date:
2018-09-05

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