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Late sodium current associated cardiac electrophysiological and mechanical dysfunction

Abstract:

Late sodium current (INaL) is a small sustained inward current observed during the cardiac action potential plateau phase following decay of the early peak INa. The endogenous INaL is relatively small in normal hearts but exerts functionally significant effects on cardiomyocyte repolarization with potentially pro-arrhythmic effects in hearts with reduced repolarization reserve. Enhanced INa,L occurs in long QT syndrome 3 (LQTS 3) patients, and under a number of pathological and pharmacologica...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1007/s00424-017-2079-7

Authors


Huang, CL-H More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
ORCID:
0000-0002-0928-341X
Publisher:
Springer Verlag Publisher's website
Journal:
Pflügers Archiv European Journal of Physiology Journal website
Volume:
470
Issue:
3
Pages:
461–469
Publication date:
2017-11-10
Acceptance date:
2017-10-09
DOI:
ISSN:
1432-2013 and 0031-6768
Pubs id:
pubs:746124
URN:
uri:3f2522d1-0028-4cf5-9f2b-195dd26123ca
UUID:
uuid:3f2522d1-0028-4cf5-9f2b-195dd26123ca
Local pid:
pubs:746124

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