Journal article
Late sodium current associated cardiac electrophysiological and mechanical dysfunction
- Abstract:
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Late sodium current (INaL) is a small sustained inward current observed during the cardiac action potential plateau phase following decay of the early peak INa. The endogenous INaL is relatively small in normal hearts but exerts functionally significant effects on cardiomyocyte repolarization with potentially pro-arrhythmic effects in hearts with reduced repolarization reserve. Enhanced INa,L occurs in long QT syndrome 3 (LQTS 3) patients, and under a number of pathological and pharmacologica...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 391.5KB)
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- Publisher copy:
- 10.1007/s00424-017-2079-7
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Authors
Funding
Bibliographic Details
- Publisher:
- Springer Verlag Publisher's website
- Journal:
- Pflügers Archiv European Journal of Physiology Journal website
- Volume:
- 470
- Issue:
- 3
- Pages:
- 461–469
- Publication date:
- 2017-11-10
- Acceptance date:
- 2017-10-09
- DOI:
- ISSN:
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1432-2013 and 0031-6768
- Pmid:
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29127493
- Source identifiers:
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746124
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:746124
- UUID:
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uuid:3f2522d1-0028-4cf5-9f2b-195dd26123ca
- Local pid:
- pubs:746124
- Deposit date:
- 2018-09-05
Terms of use
- Copyright holder:
- Springer-Verlag GmbH Germany
- Copyright date:
- 2017
- Notes:
- © Springer-Verlag GmbH Germany 2017. This is the accepted manuscript version of the article. The final version is available online from Springer Verlag at: https://doi.org/10.1007/s00424-017-2079-7
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