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Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa.

Abstract:

A polyspecific Pan-African antivenom has been produced from the plasma of horses immunized with a mixture of the venoms of Echis ocellatus, Bitis arietans and Naja nigricollis, the three most medically important snakes in sub-Saharan Africa. The antivenom is a whole IgG preparation, obtained by caprylic acid precipitation of non-IgG plasma proteins. The antivenom effectively neutralizes the most important toxic activities of the three venoms used in the immunization in standard assays involvi...

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Publication status:
Published

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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:
99
Issue:
6
Pages:
468-475
Publication date:
2005-06-05
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
URN:
uuid:3f198001-26fb-44bd-9699-1b8556d5162f
Source identifiers:
61022
Local pid:
pubs:61022

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