Journal article icon

Journal article

State-dependent network connectivity determines gating in a K+ channel.

Abstract:

X-ray crystallography has provided tremendous insight into the different structural states of membrane proteins and, in particular, of ion channels. However, the molecular forces that determine the thermodynamic stability of a particular state are poorly understood. Here we analyze the different X-ray structures of an inwardly rectifying potassium channel (Kir1.1) in relation to functional data we obtained for over 190 mutants in Kir1.1. This mutagenic perturbation analysis uncovered an exten...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.str.2014.04.018

Authors


Expand authors...
Journal:
Structure (London, England : 1993)
Volume:
22
Issue:
7
Pages:
1037-1046
Publication date:
2014-07-01
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Source identifiers:
474807
Language:
English
Pubs id:
pubs:474807
UUID:
uuid:3f16aa53-5819-442c-8a38-4328583415e4
Local pid:
pubs:474807
Deposit date:
2014-07-26

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP