Navigating the future of bacterial molecular epidemiology.

Journal article

Technological advances in high-throughput genome sequencing have led to an enhanced appreciation of the genetic diversity found within populations of pathogenic bacteria. Methods based on single nucleotide polymorphisms (SNPs) and insertions or deletions (indels) build upon the framework established by multi-locus sequence typing (MLST) and permit a detailed, targeted analysis of variation within related organisms. Robust phylogenetics, when combined with epidemiologically informative data, c...

Expand abstract

Authors: Baker, S; Hanage, W; Holt, K

• Publication status: Published
• Journal: Current opinion in microbiology
• Volume: 13
• Issue: 5
• Pages: 640-645
• Publication date: 2010-10-01
• DOI: 10.1016/j.mib.2010.08.002
• EISSN: 1879-0364
• ISSN: 1369-5274
• Language: English
• Keywords: Sequence Analysis, DNA; Genetic Variation; Molecular Epidemiology; Phylogeography; Salmonella typhi; Staphylococcal Infections; Polymorphism, Single Nucleotide; Multilocus Sequence Typing; Typhoid Fever; INDEL Mutation