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Clustered DNA damage, influence on damage excision by XRS5 nuclear extracts and Escherichia coli Nth and Fpg proteins.

Abstract:

Ionizing radiation and radiomimetic anticancer agents induce clustered DNA damage, which are thought to reflect the biological severity. Escherichia coli Nth and Fpg and nuclear extracts from XRS5, a Chinese hamster ovary Ku-deficient cell line, have been used to study the influence on their substrate recognition by the presence of a neighboring damage or an abasic site on the opposite strand, as models of clustered DNA damage. These proteins were tested for their efficiency to induce a singl...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.275.16.11865

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Journal of biological chemistry
Volume:
275
Issue:
16
Pages:
11865-11873
Publication date:
2000-04-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
131308

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