Journal article
Clustered DNA damage, influence on damage excision by XRS5 nuclear extracts and Escherichia coli Nth and Fpg proteins.
- Abstract:
-
Ionizing radiation and radiomimetic anticancer agents induce clustered DNA damage, which are thought to reflect the biological severity. Escherichia coli Nth and Fpg and nuclear extracts from XRS5, a Chinese hamster ovary Ku-deficient cell line, have been used to study the influence on their substrate recognition by the presence of a neighboring damage or an abasic site on the opposite strand, as models of clustered DNA damage. These proteins were tested for their efficiency to induce a singl...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.275.16.11865
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Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 275
- Issue:
- 16
- Pages:
- 11865-11873
- Publication date:
- 2000-04-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
131308
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:131308
- UUID:
-
uuid:3f122f7f-f158-4061-b9a7-14c9925b706c
- Local pid:
- pubs:131308
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2000
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