Journal article
Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma
- Abstract:
-
Mice infected with Citrobacter rodentium represent an excellent model in which to examine immune defenses against an attaching-effacing enteric bacterial pathogen. Colonic tissue from mice infected with C. rodentium harbors increased transcripts for IL-12 and IFN-γ and displays mucosal pathology compared with uninfected controls. In this study, the role of IL-12 and IFN-γ in host defense and mucosal injury during C. rodentium infection was examined using gene knockout mice. IL-12p40−/− and IF...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- American Association of Immunologists Publisher's website
- Journal:
- Journal of Immunology Journal website
- Volume:
- 168
- Issue:
- 4
- Pages:
- 1804-1812
- Publication date:
- 2002-02-15
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:98249
- UUID:
-
uuid:3f0e44fb-a5b4-4755-b95f-9cbbf42c7101
- Local pid:
- pubs:98249
- Source identifiers:
-
98249
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- American Association of Immunologists
- Copyright date:
- 2002
- Notes:
- Copyright © 2002 by The American Association of Immunologists. All rights reserved.
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