Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis.

Journal article

BACKGROUND: Superior temporal lobe dysfunction is a robust finding in functional neuroimaging studies of schizophrenia and is thought to be related to a disruption of fronto-temporal functional connectivity. However, the stage of the disorder at which these functional alterations occur is unclear. We addressed this issue by using functional MRI (fMRI) to study subjects in the prodromal and first episode phases of schizophrenia. METHODS: Subjects with an at risk mental state (ARMS) for psychos...

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Authors: Crossley, N; Mechelli, A; Fusar-Poli, P; Broome, MR; Matthiasson, P

• Journal: Human brain mapping
• Volume: 30
• Issue: 12
• Pages: 4129-4137
• Publication date: 2009-12-01
• DOI: 10.1002/hbm.20834
• EISSN: 1097-0193
• ISSN: 1065-9471
• Language: English
• Keywords: Humans; Schizophrenia; Brain Mapping; Image Interpretation, Computer-Assisted; Temporal Lobe; Risk Factors; Magnetic Resonance Imaging