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Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples

Abstract:

Background Acute T-cell mediated rejection (TCMR) is usually indicated by alteration in serum-creatinine measurements when considerable transplant damage has already occurred. There is, therefore, a need for non-invasive early detection of immune signals that would precede the onset of rejection, prior to transplant damage.


Methods We examined the RT-qPCR expression of 22 literature-based genes in peripheral blood samples from 248 patients in t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.ebiom.2019.01.060

Authors


Christakoudi, S More by this author
Runglall, M More by this author
Mobillo, P More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Oxford college:
Harris Manchester
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Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
41
Pages:
571-583
Publication date:
2019-03-02
Acceptance date:
2019-01-31
DOI:
EISSN:
2352-3964
Pubs id:
pubs:980198
URN:
uri:3f014db8-e0e3-470a-a624-c54ec1059e2e
UUID:
uuid:3f014db8-e0e3-470a-a624-c54ec1059e2e
Local pid:
pubs:980198
Language:
English

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