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Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5α-reductase, explaining the need for personalized glucocorticoid and androgen replacement.

Abstract:

CONTEXT: Mitotane [1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane] is the first-line treatment for metastatic adrenocortical carcinoma (ACC) and is also regularly used in the adjuvant setting after presumed complete removal of the primary tumor. Mitotane is considered an adrenolytic substance, but there is limited information on distinct effects on steroidogenesis. However, adrenal insufficiency and male hypogonadism are widely recognized side effects of mitotane treatment. OBJECTIV...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2012-2851

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Role:
Author
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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
98
Issue:
1
Pages:
161-171
Publication date:
2013-01-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:3efe7774-8b4f-4c28-a3ee-256fcee29da5
Source identifiers:
363838
Local pid:
pubs:363838

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