Journal article
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments
- Abstract:
-
Background: Enhanced macromolecule biosynthesis is integral to growth and proliferation of cancer cells. Lipid biosynthesis has been predicted to be an essential process in cancer cells. However, it is unclear which enzymes within this pathway offer the best selectivity for cancer cells and could be suitable therapeutic targets. Results: Using functional genomics, we identified stearoyl-CoA desaturase (SCD), an enzyme that controls synthesis of unsaturated fatty acids, as essential in breast ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Cancer Research UK
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Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Cancer and Metabolism Journal website
- Volume:
- 4
- Issue:
- 1
- Pages:
- 6
- Publication date:
- 2016-04-01
- Acceptance date:
- 2016-03-07
- DOI:
- EISSN:
-
2049-3002
- Pmid:
-
27042297
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:613984
- UUID:
-
uuid:3efc5690-3ccd-4e3c-8fcb-e1a40a36c935
- Local pid:
- pubs:613984
- Source identifiers:
-
613984
- Deposit date:
- 2017-06-14
Terms of use
- Copyright holder:
- Peck et al
- Copyright date:
- 2016
- Notes:
-
© 2016 Peck et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Licence:
- CC Attribution (CC BY)
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