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Natural conformational sampling of human TNFα visualized by double electron-electron resonance

Abstract:

Double electron-electron resonance in conjunction with site-directed spin labeling has been used to probe natural conformational sampling of the human tumor necrosis factor α trimer. We suggest a previously unreported, predeoligomerization conformation of the trimer that has been shown to be sampled at low frequency. A model of this trimeric state has been constructed based on crystal structures using the double-electron-electron-resonance distances. The model shows one of the protomers to be...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.bpj.2017.06.007

Authors


Carrington, B More by this author
More by this author
Department:
Oxford, MPLS, Chemistry, Inorganic Chemistry
Horanyi, P More by this author
Calmiano, M More by this author
Lawson, ADG More by this author
Publisher:
Biophysical Society Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
113
Issue:
2
Pages:
371-380
Publication date:
2017-07-25
Acceptance date:
2017-06-06
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Pubs id:
pubs:709609
URN:
uri:3ef9ceb5-b3d9-4772-a6ff-c5b59179fa94
UUID:
uuid:3ef9ceb5-b3d9-4772-a6ff-c5b59179fa94
Local pid:
pubs:709609
Language:
English
Keywords:

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