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Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells.

Abstract:

Insulin is produced and secreted by the B cells in the endocrine pancreas. In vivo, insulin secretion is under the control of a number of metabolic, neural and hormonal substances. It is now clear that stimulation of insulin release by fuel secretagogues, such as glucose, involves the closure of K+ channels that are sensitive to the intracellular ATP concentration (KATP channels). This leads to membrane depolarization and the generation of Ca2(+)-dependent action potentials. The mechanisms wh...

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Publication status:
Published

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Publisher copy:
10.1038/349077a0

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Bokvist, K More by this author
Ammälä, C More by this author
Arkhammar, P More by this author
Berggren, PO More by this author
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Journal:
Nature
Volume:
349
Issue:
6304
Pages:
77-79
Publication date:
1991-01-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:3ef0582e-b394-4ef4-b18f-6893c3357b3e
Source identifiers:
3801
Local pid:
pubs:3801

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