- Abstract:
-
Insulin is produced and secreted by the B cells in the endocrine pancreas. In vivo, insulin secretion is under the control of a number of metabolic, neural and hormonal substances. It is now clear that stimulation of insulin release by fuel secretagogues, such as glucose, involves the closure of K+ channels that are sensitive to the intracellular ATP concentration (KATP channels). This leads to membrane depolarization and the generation of Ca2(+)-dependent action potentials. The mechanisms wh...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/349077a0
-
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- Journal:
- Nature
- Volume:
- 349
- Issue:
- 6304
- Pages:
- 77-79
- Publication date:
- 1991-01-05
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- URN:
-
uuid:3ef0582e-b394-4ef4-b18f-6893c3357b3e
- Source identifiers:
-
3801
- Local pid:
- pubs:3801
- Language:
- English
- Keywords:
- Copyright date:
- 1991
Journal article
Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells.
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