Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of α-glucosidases than the enantiomeric natural product DMDP
- L-DMDP, prepared from D-gulonolactone, is a highly specific inhibitor of a number of plant and mammalian α-glucosidases [between 2 and 4 orders of magnitude more potent than the enantiomeric natural product DMDP] but is not an inhibitor of bacterial and yeast α-glucosidases. Additionally N-butyl-DMDP is a potent inhibitor of ceramide-specific glucosyl-transferase but N-butyl-L-DMDP shows no inhibition.
- Publisher copy:
- Copyright date:
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record