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Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of α-glucosidases than the enantiomeric natural product DMDP

Abstract:
L-DMDP, prepared from D-gulonolactone, is a highly specific inhibitor of a number of plant and mammalian α-glucosidases [between 2 and 4 orders of magnitude more potent than the enantiomeric natural product DMDP] but is not an inhibitor of bacterial and yeast α-glucosidases. Additionally N-butyl-DMDP is a potent inhibitor of ceramide-specific glucosyl-transferase but N-butyl-L-DMDP shows no inhibition.

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Publisher copy:
10.1039/b406035k

Authors


Butters, TD More by this author
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Journal:
Chemical Communications
Volume:
10
Issue:
17
Pages:
1936-1937
Publication date:
2004-09-07
DOI:
ISSN:
1359-7345
URN:
uuid:3eef2c25-d592-47f5-b3d8-7f4664dd6f68
Source identifiers:
101095
Local pid:
pubs:101095
Language:
English

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