Journal article
PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer
- Abstract:
-
Tumour cells can use strategies that make them resistant to nutrient deprivation to outcompete their neighbours. A key integrator of the cell’s responses to starvation and other stresses is amino-acid-dependent mechanistic target of rapamycin complex 1 (mTORC1). Activation of mTORC1 on late endosomes and lysosomes is facilitated by amino-acid transporters within the solute-linked carrier 36 (SLC36) and SLC38 families. Here, we analyse the functions of SLC36 family member, SLC36A4, otherwise k...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Wellcome Trust
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Biotechnology and Biological Sciences Research Council
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Cancer Research UK
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Oncogene Journal website
- Volume:
- 35
- Pages:
- 3004–3015
- Publication date:
- 2015-10-05
- DOI:
- EISSN:
-
1476-5594
- ISSN:
-
0950-9232
Item Description
- Pubs id:
-
pubs:571025
- UUID:
-
uuid:3eed4dcf-4f07-4520-88d4-89fcd811fbba
- Local pid:
- pubs:571025
- Source identifiers:
-
571025
- Deposit date:
- 2015-10-19
Terms of use
- Copyright holder:
- Macmillan Publishers Limited
- Copyright date:
- 2015
- Notes:
- Copyright © 2015 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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