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AMP-Activated protein kinase phosphorylates cardiac troponin i and alters contractility of murine ventricular myocytes

Abstract:

Rationale: AMP-activated protein kinase (AMPK) is an important regulator of energy balance and signaling in the heart. Mutations affecting the regulatory γ2 subunit have been shown to cause an essentially cardiac-restricted phenotype of hypertrophy and conduction disease, suggesting a specific role for this subunit in the heart. Objective: The γ isoforms are highly conserved at their C-termini but have unique N-terminal sequences, and we hypothesized that the N-terminus of γ2 may be involved ...

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Authors


Oliveira, SM More by this author
Zhang, Y-H More by this author
Isackson, H More by this author
Bellahcene, M More by this author
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Journal:
Circulation Research
Volume:
110
Issue:
9
Pages:
1192-1201
Publication date:
2012-04-27
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:3ee87309-259f-4c77-8094-9a4daec61b24
Source identifiers:
341519
Local pid:
pubs:341519

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