Journal article
AMP-Activated protein kinase phosphorylates cardiac troponin i and alters contractility of murine ventricular myocytes
- Abstract:
-
Rationale: AMP-activated protein kinase (AMPK) is an important regulator of energy balance and signaling in the heart. Mutations affecting the regulatory γ2 subunit have been shown to cause an essentially cardiac-restricted phenotype of hypertrophy and conduction disease, suggesting a specific role for this subunit in the heart. Objective: The γ isoforms are highly conserved at their C-termini but have unique N-terminal sequences, and we hypothesized that the N-terminus of γ2 may be involved ...
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- Publisher copy:
- 10.1161/CIRCRESAHA.111.259952
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Bibliographic Details
- Journal:
- Circulation Research
- Volume:
- 110
- Issue:
- 9
- Pages:
- 1192-1201
- Publication date:
- 2012-04-27
- DOI:
- EISSN:
-
1524-4571
- ISSN:
-
0009-7330
- URN:
-
uuid:3ee87309-259f-4c77-8094-9a4daec61b24
- Source identifiers:
-
341519
- Local pid:
- pubs:341519
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2012
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