- Abstract:
- We examined adenomas and cancers from hereditary non-polyposis colorectal cancer (HNPCC) syndrome patients for the presence of frameshift mutations in the smooth-muscle myosin gene, MYH11. Our results show that mutations in MYH11 occur more frequently in cancers than adenomas (P=0.008) and are dependent on microsatellite instability (MSI+).
- Publication status:
- Published
- Publisher copy:
- 10.1038/sj.bjc.6604737
-
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- Journal:
- British journal of cancer
- Volume:
- 99
- Issue:
- 10
- Pages:
- 1726-1728
- Publication date:
- 2008-11-05
- DOI:
- EISSN:
-
1532-1827
- ISSN:
-
0007-0920
- URN:
-
uuid:3ee59319-a596-4758-a481-30e4667350ed
- Source identifiers:
-
72070
- Local pid:
- pubs:72070
- Copyright date:
- 2008
Journal article
Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome.
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