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Journal article

"Infectious" transplantation tolerance.

Abstract:

The maintenance of transplantation tolerance induced in adult mice after short-term treatment with nonlytic monoclonal antibodies to CD4 and CD8 was investigated. CD4+ T cells from tolerant mice disabled naïve lymphocytes so that they too could not reject the graft. The naïve lymphocytes that had been so disabled also became tolerant and, in turn, developed the capacity to specifically disable other naïve lymphocytes. This process of "infectious" tolerance explains why no further immunosuppre...

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Publication status:
Published

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Publisher copy:
10.1126/science.8094901

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Journal:
Science (New York, N.Y.)
Volume:
259
Issue:
5097
Pages:
974-977
Publication date:
1993-02-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Source identifiers:
20284

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