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An ATF/CREB binding motif is required for aberrant constitutive expression of the MHC class II DR alpha promoter and activation by SV40 T-antigen.

Abstract:

Constitutive expression of major histocompatibility complex class II (MHC II) antigens normally occurs in B-lymphocytes and antigen presenting cells of the monocyte/macrophage lineage. However, many malignant tumours and transformed cells express these proteins aberrantly. We demonstrate here that the MHC II DR alpha promoter is constitutively active both in the SV40 large T antigen transformed cell line, COS, and in CV1 cells from which they are derived. As an approach to understanding the m...

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Publication status:
Published

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Publisher copy:
10.1093/nar/20.18.4881

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Journal:
Nucleic acids research
Volume:
20
Issue:
18
Pages:
4881-4887
Publication date:
1992-09-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:3ee2a382-1c61-4fef-b33f-77f06919f9f3
Source identifiers:
92934
Local pid:
pubs:92934

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