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Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding protein genes in Mus musculus

Abstract:

Background: The genes for salivary androgen-binding protein (ABP) subunits have been evolving rapidly in ancestors of the house mouse Mus musculus, as evidenced both by recent and extensive gene duplication and by high ratios of nonsynonymous to synonymous nucleotide substitution rates. This makes ABP an appropriate model system with which to investigate how recent adaptive evolution of paralogous genes results in functional innovation (neofunctionalization). Results: It was our goal to find...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2148-5-40

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Institution:
Butler University (Indianapolis, Indiana)
Department:
Internal Medicine Residency Program,St. Vincent Hospital
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Institution:
Indiana University School of Medicine
Department:
Department of Medical and Molecular Genetics
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Institution:
University College London
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Institution:
University of Oxford
Department:
MRC Functional Genetics Unit
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Institution:
Butler University (Indianapolis, Indiana)
Department:
Department of Biological Sciences
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Funding agency for:
Richard D Emes
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Funding agency for:
Chris P Ponting
Publisher:
BioMed Central
Journal:
BMC Evolutionary Biology Journal website
Volume:
5
Pages:
Article: 40
Publication date:
2005
DOI:
ISSN:
1471-2148
URN:
uuid:3ee2448f-6621-47de-bec4-a998eabcfae0
Local pid:
ora:2286
Language:
English
Keywords:
Subjects:

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