CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse.

Journal article

The binding of costimulatory ligand CD80 to CD28 or CTLA-4 on T cells plays an important role in the regulation of the T cell response. We have examined the role of the cytoplasmic domain of CD80 in murine T cell costimulation and its organization in the immunological synapse (IS). Removal of CD80 cytoplasmic tail decreased its effectiveness in costimulating T cell proliferative response and early IL-2 production in response to agonist MHC-peptide complexes. Immunofluorescent study showed a d...

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Authors: Tseng, S; Liu, M; Dustin, M

• Journal: Journal of Immunology
• Volume: 175
• Issue: 12
• Pages: 7829-7836
• Publication date: 2005-12-01
• DOI: 10.4049/jimmunol.175.12.7829
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Protein Structure, Tertiary; Animals; Signal Transduction; CHO Cells; Antigen-Presenting Cells; Protein Kinase C; Cricetinae; Antigens, CD28; CTLA-4 Antigen; Mice; Antigens, CD80; T-Lymphocytes; Antigens, CD; Multiprotein Complexes; Mice, Transgenic; Cytoplasm; Antigens, Differentiation; Isoenzymes; Transfection; Lymphocyte Activation