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Journal article

In vitro and in vivo evaluation of [123I]-VEGF165 as a potential tumor marker.

Abstract:

One of the research challenges in oncology is to develop new biochemical methods for noninvasive tumor therapy evaluation to determine whether the chemotherapeutics is effective. Vascular endothelial growth factor (VEGF) was labeled with radioiodine and evaluated in vitro as well as in vivo, using A2058, a melanoma cell line overexpressing VEGFR-1 and -2. Saturation binding analysis with [(125)I]-VEGF resulted in a K(d) of 0.1 nM. Internalization assays indicate the preserved ligand induced i...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Journal:
Nuclear medicine and biology
Volume:
32
Issue:
5
Pages:
431-436
Publication date:
2005-07-01
DOI:
EISSN:
1872-9614
ISSN:
0969-8051
Source identifiers:
259094
Language:
English
Keywords:
Pubs id:
pubs:259094
UUID:
uuid:3ee0154d-45d7-478b-9c45-ebf427d2732b
Local pid:
pubs:259094
Deposit date:
2013-11-17

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