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Harnessing the potential of adult cardiac stem cells: lessons from haematopoiesis, the embryo and the niche.

Abstract:

Across biomedicine, there is a major drive to develop stem cell (SC) treatments for debilitating diseases. Most effective treatments restore an embryonic phenotype to adult SCs. This has led to two emerging paradigms in SC biology: the application of developmental biology studies and the manipulation of the SC niche. Developmental studies can reveal how SCs are orchestrated to build organs, the understanding of which is important in order to instigate tissue repair in the adult. SC niche stud...

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Publication status:
Published

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Publisher copy:
10.1007/s12265-012-9386-3

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Journal:
Journal of cardiovascular translational research
Volume:
5
Issue:
5
Pages:
631-640
Publication date:
2012-10-05
DOI:
EISSN:
1937-5395
ISSN:
1937-5387
URN:
uuid:3edbd7e0-ab5e-4414-a203-a572594d1235
Source identifiers:
339921
Local pid:
pubs:339921

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