Journal article icon

Journal article

Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor.

Abstract:

Despite decades of research in the epidermal growth factor receptor (EGFR) signalling field, and many targeted anti-cancer drugs that have been tested clinically, the success rate for these agents in the clinic is low, particularly in terms of the improvement of overall survival. Intratumoral heterogeneity is proposed as a major mechanism underlying treatment failure of these molecule-targeted agents. Here we highlight the application of fluorescence lifetime microscopy (FLIM)-based biosensin...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1038/onc.2016.522

Authors


Weitsman, G More by this author
More by this author
ORCID:
0000-0002-9041-1852
Kalber, TL More by this author
Expand authors...
Medical Research Council More from this funder
UK Department of Health More from this funder
Expand funders...
Publisher:
Nature Publishing Group Publisher's website
Journal:
Oncogene Journal website
Volume:
36
Issue:
25
Pages:
3618-3628
Publication date:
2017-02-05
Acceptance date:
2016-12-21
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
Pubs id:
pubs:679143
URN:
uri:3eda91f6-a25b-4bd4-bd4b-587a3809da2f
UUID:
uuid:3eda91f6-a25b-4bd4-bd4b-587a3809da2f
Local pid:
pubs:679143

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP