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NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation.

Abstract:

Breast cancer is genetically heterogeneous, and recent studies have underlined a prominent contribution of epigenetics to the development of this disease. To uncover new synthetic lethalities with known breast cancer oncogenes, we screened an epigenome-focused short hairpin RNA library on a panel of engineered breast epithelial cell lines. Here we report a selective interaction between the NOTCH1 signaling pathway and the SUMOylation cascade. Knockdown of the E2-conjugating enzyme UBC9 (UBE2I...

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Publisher copy:
10.1038/onc.2014.319

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Journal:
Oncogene
Publication date:
2014-09-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:3ec87bde-1a65-465a-88cb-32baaf76e916
Source identifiers:
490920
Local pid:
pubs:490920
Language:
English

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