- Abstract:
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Breast cancer is genetically heterogeneous, and recent studies have underlined a prominent contribution of epigenetics to the development of this disease. To uncover new synthetic lethalities with known breast cancer oncogenes, we screened an epigenome-focused short hairpin RNA library on a panel of engineered breast epithelial cell lines. Here we report a selective interaction between the NOTCH1 signaling pathway and the SUMOylation cascade. Knockdown of the E2-conjugating enzyme UBC9 (UBE2I...
Expand abstract - Publisher copy:
- 10.1038/onc.2014.319
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- Journal:
- Oncogene
- Publication date:
- 2014-09-05
- DOI:
- EISSN:
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1476-5594
- ISSN:
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0950-9232
- URN:
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uuid:3ec87bde-1a65-465a-88cb-32baaf76e916
- Source identifiers:
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490920
- Local pid:
- pubs:490920
- Language:
- English
- Copyright date:
- 2014
Journal article
NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation.
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