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DNA/long peptide vaccination against conserved regions of SIV induces partial protection against SIVmac251 challenge.

Abstract:

OBJECTIVES: We recently developed a HIVconsv vaccine strategy, consisting of combined conserved regions of HIV-1, to adequately cover viral diversity. To evaluate efficacy in nonhuman primates, an equivalent SIV-derived immunogen SIVconsv was designed and delivered as plasmid DNA or synthetic long peptides. DESIGN: Rhesus macaques lacking protective MHC class I alleles Mamu-A*001 : 01, B*008 : 01, B*017 : 01 were immunized with either SIVconsv synthetic long peptides (S) alone or in combinati...

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Publication status:
Published

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Authors


Koopman, G More by this author
Beenhakker, N More by this author
Nieuwenhuis, I More by this author
Doxiadis, G More by this author
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Journal:
AIDS (London, England)
Volume:
27
Issue:
18
Pages:
2841-2851
Publication date:
2013-11-05
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
URN:
uuid:3ec6f166-686a-4dab-a0d8-f26e519b916b
Source identifiers:
434355
Local pid:
pubs:434355

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