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Transcriptional activity of the human pseudogene psi alpha globin compared with alpha globin, its functional gene counterpart.

Abstract:

Transcriptional analysis of the human pseudogene psi alpha globin has revealed the following features: (1) The promoter with a 23 bp deletion between the CCAAT and ATA boxes is functional both in vitro and in vivo, 3 fold and 10 fold less efficient, respectively, than alpha. (2) Both the psi alpha and alpha globin gene promoters are active in the absence of transcriptional enhancers, either a gene-encoded or viral enhancer. (3) The mutated poly(A) addition signal in psi alpha (AATGAA) appears...

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Publication status:
Published

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Publisher copy:
10.1093/nar/11.22.7717

Authors


Whitelaw, E More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Nucleic acids research
Volume:
11
Issue:
22
Pages:
7717-7733
Publication date:
1983-11-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:3ec6e264-1ec1-4817-b595-ae4fe674a7ce
Source identifiers:
22964
Local pid:
pubs:22964

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