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Targeting blood-brain-barrier transcytosis – perspectives for drug delivery

Abstract:

Efficient transcytosis across the blood-brain-barrier (BBB) is an important strategy for accessing drug targets within the central nervous system (CNS). Despite extensive research the number of studies reporting successful delivery of macromolecules or macromolecular complexes to the CNS has remained very low. In order to expand current research it is important to know which receptors are selective and abundant on the BBB so that novel CNS-targeting antibodies or other ligands could be develo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.neuropharm.2016.08.025

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Grant:
Joint Undertaking under grant agreement no. 115363
Publisher:
Elsevier
Journal:
Neuropharmacology More from this journal
Volume:
120
Pages:
4–7
Publication date:
2016-08-22
Acceptance date:
2016-08-19
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
Keywords:
Pubs id:
pubs:640174
UUID:
uuid:3ec2c5d2-d789-4681-b405-761d648de311
Local pid:
pubs:640174
Source identifiers:
640174
Deposit date:
2016-08-22

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