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Journal article

Drug delivery strategies for platinum-based chemotherapy

Abstract:

Few chemotherapeutics have had such an impact on cancer management as cis-diamminedichloridoplatinum(II) (CDDP), also known as cisplatin. The first member of the platinum based drug family, CDDP’s potent toxicity in disrupting DNA replication has led to its widespread use in multi-drug therapies, with particular benefit in patients with testicular cancers. However, CDDP also produces significant side effects that limit the maximum systemic dose. Various strategies have been developed to addre...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1021/acsnano.7b04092

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Department:
Oxford, MSD, Oncology
Role:
Author
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Publisher:
American Chemical Society Publisher's website
Journal:
ACS Nano Journal website
Volume:
11
Issue:
9
Pages:
8560-8578
Publication date:
2017-08-22
Acceptance date:
2017-08-22
DOI:
EISSN:
1936-086X
ISSN:
1936-0851
Pubs id:
pubs:724043
URN:
uri:3ebfd19f-5353-4f14-98f0-db17edbb510f
UUID:
uuid:3ebfd19f-5353-4f14-98f0-db17edbb510f
Local pid:
pubs:724043

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