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Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial.

Abstract:

BACKGROUND: 6-mercaptopurine has been a standard component of long-term continuing treatment for childhood lymphoblastic leukaemia, whereas 6-thioguanine has been mainly used for intensification courses. Since preliminary data have shown that 6-thioguanine is more effective than 6-mercaptopurine, we compared the efficacy and toxicity of the two drugs for childhood lymphoblastic leukaemia. METHODS: Consecutive children with lymphoblastic leukaemia diagnosed in the UK and Ireland between April,...

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Publication status:
Published

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Authors


Mitchell, CD More by this author
Lennard, L More by this author
Kinsey, SE More by this author
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Journal:
Lancet
Volume:
368
Issue:
9544
Pages:
1339-1348
Publication date:
2006-10-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:3ebe2083-f4b9-48d7-ac58-6c1f0b1850b2
Source identifiers:
88449
Local pid:
pubs:88449

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