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An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo.

Abstract:
Embryonic stem cells (ES) cells were injected into host blastocysts either in groups of 10-15 cells or as single cells in order to test their developmental potential in the developing embryo. The analysis of midgestation chimaeras, by electrophoretic separation of glucose phosphate isomerase (GPI) isozymes, showed that ES cells were capable of colonizing trophectoderm and primitive endoderm derivatives at a low frequency, as well as producing a high rate of chimaerism in tissues of the fetus and extraembryonic mesoderm.

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Journal:
Development (Cambridge, England)
Volume:
105
Issue:
4
Pages:
733-737
Publication date:
1989-04-05
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:3eb2ef5a-5d36-452d-be8e-7d1060d1d98f
Source identifiers:
245662
Local pid:
pubs:245662

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