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SYNTHESIS FROM D-GLUCOSE OF 1,5-DIDEOXY-1,5-IMINO-L-FUCITOL, A POTENT ALPHA-L-FUCOSIDASE INHIBITOR

Abstract:
1,5-Dideoxy-1,5-imino-L-fucitol (1), synthesised from methyl α-D-glucopyranoside, is a potent competitive inhibitor of the hydrolysis of p-nitrophenyl α-L-fucopyranoside catalysed by α-L-fucosidase (ex. bovine epididymis) causing 50% inhibition of enzymic activity at 2.5 × 10 -8 M.
Publication status:
Published

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Publisher copy:
10.1039/c39850000841

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Journal:
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS
Issue:
13
Pages:
841-842
Publication date:
1985
DOI:
ISSN:
0022-4936
URN:
uuid:3eaa444b-91d2-4fdc-a8bc-47de8ca32b0d
Source identifiers:
42508
Local pid:
pubs:42508
Language:
English

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