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Journal article

Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response.

Abstract:

There is an association between expression of the MHC class I molecule HLA-B27 and protection following human infection with either HIV or HCV. In both cases, protection has been linked to HLA-B27 presentation of a single immunodominant viral peptide epitope to CD8+ T cells. If HIV mutates the HLA-B27-binding anchor of this epitope to escape the protective immune response, the result is a less-fit virus that requires additional compensatory clustered mutations. Here, we sought to determine wh...

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Publication status:
Published

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Publisher copy:
10.1172/jci36587

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Journal:
The Journal of clinical investigation
Volume:
119
Issue:
2
Pages:
376-386
Publication date:
2009-02-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:3ea6ebc4-ffb7-41a6-98ac-210489d9e6d0
Source identifiers:
6712
Local pid:
pubs:6712

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