Host iron binding proteins acting as niche indicators for Neisseria meningitidis.

Journal article

Neisseria meningitidis requires iron, and in the absence of iron alters its gene expression to increase iron acquisition and to make the best use of the iron it has. During different stages of colonization and infection available iron sources differ, particularly the host iron-binding proteins haemoglobin, transferrin, and lactoferrin. This study compared the transcriptional responses of N. meningitidis, when grown in the presence of these iron donors and ferric iron, using microarrays.Specif...

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Authors: Jordan, P; Saunders, N

• Publication status: Published
• Journal: PloS one
• Volume: 4
• Issue: 4
• Pages: e5198
• Publication date: 2009-01-01
• DOI: 10.1371/journal.pone.0005198
• EISSN: 1932-6203
• ISSN: 1932-6203
• Language: English
• Keywords: Iron-Binding Proteins; Oligonucleotide Array Sequence Analysis; Neisseria meningitidis; Polymerase Chain Reaction; Transferrin; Culture Media; Lactoferrin; Gene Expression Regulation, Bacterial; Up-Regulation; Hemoglobins; Genes, Bacterial