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Asymmetry of chromosome Replichores renders the DNA translocase activity of FtsK essential for cell division and cell shape maintenance in Escherichia coli.

Abstract:

Bacterial chromosomes are organised as two replichores of opposite polarity that coincide with the replication arms from the ori to the ter region. Here, we investigated the effects of asymmetry in replichore organisation in Escherichia coli. We show that large chromosome inversions from the terminal junction of the replichores disturb the ongoing post-replicative events, resulting in inhibition of both cell division and cell elongation. This is accompanied by alterations of the segregation p...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pgen.1000288

Authors


Lesterlin, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Dasgupta, S More by this author
Journal:
PLoS genetics
Volume:
4
Issue:
12
Pages:
e1000288
Publication date:
2008-12-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:3e9719e4-83d9-4246-b684-d0919197db63
Source identifiers:
55366
Local pid:
pubs:55366

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