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Journal article

Intrapleural use of tissue plasminogen activator and DNase in pleural infection.

Abstract:

BACKGROUND: More than 30% of patients with pleural infection either die or require surgery. Drainage of infected fluid is key to successful treatment, but intrapleural fibrinolytic therapy did not improve outcomes in an earlier, large, randomized trial. METHODS: We conducted a blinded, 2-by-2 factorial trial in which 210 patients with pleural infection were randomly assigned to receive one of four study treatments for 3 days: double placebo, intrapleural tissue plasminogen activator (t-PA) an...

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Publication status:
Published

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Publisher copy:
10.1056/nejmoa1012740

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Journal:
New England journal of medicine
Volume:
365
Issue:
6
Pages:
518-526
Publication date:
2011-08-01
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Source identifiers:
170096
Language:
English
Keywords:
Pubs id:
pubs:170096
UUID:
uuid:3e8d8c90-297a-4ddf-9b2a-6dceb88ecb0b
Local pid:
pubs:170096
Deposit date:
2012-12-19

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