Journal article
Semisynthetic nanoreactor for reversible single-molecule covalent chemistry.
- Abstract:
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Protein engineering has been used to remodel pores for applications in biotechnology. For example, the heptameric α-hemolysin pore (αHL) has been engineered to form a nanoreactor to study covalent chemistry at the single-molecule level. Previous work has been confined largely to the chemistry of cysteine side chains or, in one instance, to an irreversible reaction of an unnatural amino acid side chain bearing a terminal alkyne. Here, we present four different αHL pores obtained by coupling ei...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.6MB, Terms of use)
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- Publisher copy:
- 10.1021/acsnano.6b04663
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Bibliographic Details
- Publisher:
- American Chemical Society
- Journal:
- ACS Nano More from this journal
- Volume:
- 10
- Issue:
- 9
- Pages:
- 8843-8850
- Publication date:
- 2016-08-01
- Acceptance date:
- 2016-08-18
- DOI:
- EISSN:
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1936-086X
- ISSN:
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1936-0851
- Pmid:
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27537396
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:640499
- UUID:
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uuid:3e8ab6d7-fe14-4303-afdc-1373e1e27fbf
- Local pid:
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pubs:640499
- Source identifiers:
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640499
- Deposit date:
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2017-10-19
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 American Chemical Society. ACS AuthorChoice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
- Licence:
- Other
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